Plavix is the brand name form of the generic drug clopidogrel bisulfate, an anti-platelet medication that's used to prevent blood clots. Blood clots can form in blood as a result of certain heart. Plagril Tablets (Generic Plavix) - Dosage. The dosing for Generic Plavix is as follows: Acute coronary syndrome - Non-ST-segment elevation ACS (UA/NSTEMI): 300 mg loading dose followed by 75 mg once daily, in combination with aspirin (75-325 mg once daily) Plavix Tablets Dose should be given as a single daily dose of Clopidogrel 75 mg. Acute Coronary Syndrome For patients with non-ST-segment elevation acute coronary syndrome (unstable angina/non-Q-wave MI), Plavix Tablets should initiated with a single 300-mg loading dose and then continued at Plavix 75 mg once daily. Plavix carries out its antiplatelet action by binding to the surface of platelets and deactivating their ability to clump together. While you may be given a prescription for Plavix to prevent unwanted blood clots, the medication can also cause excessive bleeding— which is its most common side effect. Find patient medical information for Plavix Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The recommended dose is 75 mg per day for patient with a history of MI, stroke, or peripheral vascular disease. Many doctors may choose to add an aspirin per day along with the Plavix dose in both non-ST elevation and ST elevation MIs as well as to stroke and peripheral vascular disease patients. Clopidogrel oral tablet is available as both a generic and brand-name drug. Brand name: Plavix. Clopidogrel only comes in the form of a tablet you take by mouth. Clopidogrel is used to prevent. The use of Plavix in CURE was associated with a decrease in the use of thrombolytic therapy (71 patients [1.1%] in the Plavix group, 126 patients [2.0%] in the placebo group; relative risk reduction of 43%), and GPIIb/IIIa inhibitors (369 patients [5.9%] in the Plavix group, 454 patients [7.2%] in the placebo group, relative risk reduction of 18%). Medscape - Indication-specific dosing for Plavix (clopidogrel), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. In patients who need an antiplatelet effect within hours, initiate Plavix with a single 300 mg oral loading dose and then continue at 75 mg once daily. Initiating Plavix without a loading dose will delay establishment of an antiplatelet effect by several days [see Clinical Pharmacology (12.3) and Clinical Studies (14.1)].